Epigenetic regulation of miR-218 and its host gene, SLIT2 in breast cancer
نویسنده
چکیده
Numerous studies have shown that microRNAs are deregulated in various types of cancer. Although miR‑218 aberrant expression has been documented in various cancers, the epigenetic regulation of miR-218 is unclear in breast cancer. Our results demonstrate that treatment of breast cancer cells with demethylating agent, 5-azacytidine, resulted in increased expression of miR-218 and its host gene slit-2, suggesting that they are epigenetically regulated in breast cancer. The ectopic expression of miR‑218 sensitize breast cancer cell to doxorubicin treatment. The results suggest that miR-218 is epigenetically regulated along with its host gene and function as a tumor suppressor in breast cancer. miR-218 and SLIT2 may have potential therapeutic value in combination with demethylating drug in breast cancer patients.. CC-BY-NC-ND 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was .
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